Biodistribution, pharmacokinetics, and toxicity of dendrimer. Factors controlling the pharmacokinetics, biodistribution. Jun 12, 20 pectin, a naturally occurring biopolymer has been found to have increasing applications in the pharmaceutical and biotechnology industry. Pharmacokinetics, biodistribution, and pharmacodynamics of. Biodistribution and physiologicallybased pharmacokinetic. Pk is often defined simply as what the body does to the drug, and is typically described using four critical processes. Rapid particle uptake and tissue distribution were observed, without adverse reactions, in primary bloodderived and tissue macrophages. Dec 28, 20 the physicochemical properties of nanoparticles such as size, shape, surface charge, surface chemistry pegylation, ligand conjugation and composition affect the pharmacokinetics, biodistribution, intratumoral penetration and tumor bioavailability. The bvp content in the nps, the biological samples and in. Pharmacokinetics, pharmacodynamics and toxicology of. Nanoparticle, pharmacokinetics, biodistribution, tumor.
Transmission electron microscopy studies on optftc nps. Pharmacokinetics and biodistribution of the nanoparticles. Small interfering rna sirna is effective in silencing critical molecular pathways in cancer. The pharmacokinetics of dtx was found to be improved with an increase in auc 5. Pharmacokinetics and biodistribution of the nanoparticles nanotechnology is an emerging and promising technique, giving pavement to a novel therapeutic domain, i. Effects of particle size and pegylation qianjun he state key laboratory of high performance ceramics and superfine microstructure, shanghai institute of ceramics, chinese academy of sciences, 1295 ding. Uptake and biodistribution of nanoparticles kemikalieinspektionen.
Pharmacokinetics and biodistribution of nanoparticles american. In this paper we report the biodistribution and pharmacokinetic properties of tobacco mosaic virus tmv in the forms of. Factors affecting the pharmacokinetics, biodistribution. Steinmetza,b,c,d,n a department of biomedical engineering, case western reserve university, 10900 euclid avenue, cleveland, oh 44106.
A phase 0 study of the pharmacokinetics, biodistribution, and. While surface properties such as charge are expected to play an important role in their in vivo behavior, very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution. Molecules and particles as nano and microscale drug carriers last time. In several preclinical studies with various tumorbearing mice models, 188reliposome that has been developed by the institute of nuclear energy research iner demonstrates favorable in vivo tumor targeting, biodistribution, pharmacokinetics, and dosimetry. Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs prepared by. However, isolation of the fundamental effects of the materials employed to modify the. The polymercoated nanoparticles were observed in the lung, liver and spleen. The latter was seen within the marginal zones of spleen. Absorption, biodistribution, elimination and pharmacologic and toxic effects. Gold nanoparticles aunps are a focus of growing medical research applications due to their unique chemical, electrical and optical properties. Molecules and particles as nano and microscale drug carriers.
Although biological studies have shown ceo2 nanoparticles can cause adverse health effects, the extent of the biodistribution of ceo2 nanoparticles through inhalation has not been well characterized. Factors affecting the pharmacokinetics, biodistribution and toxicity of gold nanoparticles in drug delivery authors. Jul 11, 2014 through proper design and formulation of the chemical and physical properties of the nanoparticle, including surface chemistry and hydrodynamic radius, the pharmacokinetics and biodistribution can. The biodistribution is the consequence resulting from two factors. Csircentral drug research institute, lucknow 226031, india. Pharmacokinetics and biodistribution of nanoparticles. Formulation, pharmacokinetics and biodistribution of ofloxacinloaded albumin microparticles and nanoparticles article pdf available in journal of microencapsulation 285. Opsonization is the process by which a foreign organism or particle becomes covered with opsonin proteins, thereby making it more visible to phagocytic cells. The objective of this study is to investigate the pharmacokinetics and biodistribution of free breviscapine bvp and coated bvploaded poly d, llactic acid nanoparticles bvpplanps in rats after i. Randolpha, allen vanmetera, stephen herna, andrew j. The final biodistribution of this sequestration depends on several factors and is discussed in more detail in the biodistribution and pharmacokinetics section of this paper. Initial plasma concentration c initial of 14 csinps was determined to be 154.
Controlling in viv o stability and biodistribution in. In this study, we investigated the pharmacokinetics, biodistribution, and tumor uptake of subnanometer sized polymeric nanoparticles pharmacokinetics, and blood compatibility of native and pegylated tobacco mosaic virus nano rods and spheres in mice michael a. A pharmacokinetics and biodistribution study with endpoints at 2, 6, 24, and 48 h performed in normal and tumorbearing, inbred balbc mice showed accumulation in liver and tumor with pgn. Biodistribution and pharmacokinetics study of sirnaloaded. Nanoparticles display distinctive pharmacokinetics pk and biodistribution bd. Jun 12, 20 read pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel, cancer nanotechnology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The calculated mean pharmacokinetic parameters are presented in table 1. Simple and tunable surface coatings via polydopamine for. Biodistribution, pharmacokinetics, and toxicity of dendrimercoated iron oxide nanoparticles in balbc mice marzieh salimi,1,2 saeed sarkar,1,2 samaneh fathi,3 ali mohammad alizadeh,4 reza saber,2,3 fatemeh moradi,5 hamid delavari6 1department of medical physics and biomedical engineering, tehran university of medical sciences, tehran, iran. Nanotechnology is an emerging and promising technique, giving pavement to a novel therapeutic domain, i. Biodistribution, pharmacokinetics, and blood compatibility of. Pharmacokinetics and biodistribution of 86ytrastuzumab for 90y dosimetry in an ovarian carcinoma model. Murthy drug delivery research laboratory, center of relevance and excellence in ndds, pharmacy department, g. After opsonization, phagocytosis can occur, which is the engulfing and eventual destruction or removal of foreign materials from the bloodstream.
Pharmacokinetics and biodistribution of negatively. Chemical and physical properties of the nanoparticles, including size, surface charge, and surface chemistry, are important factors that determine their pk and biodistribution. Comparison of biodistribution and biocompatibility of. Pharmacokinetic, pharmacodynamic and biodistribution. Pdf nanotechnology is an emerging and promising technique, giving pavement to a novel therapeutic domain, i. Pharmacokinetics of nanoparticleloaded drug s is generally concerned with four components.
Oct 31, 2017 pharmacokinetic, pharmacodynamic and biodistribution following oral 1. Pharmacokinetics and in vivo biodistribution of optimized. Antitubulin agents are the most potent and broadest spectrum drugs for cancer therapy, including taxanes and vinca alkaloids. Inhalable rapamycin rap particles targeting lung macrophages were prepared to. This is a pdf file of an unedited manuscript that has been accepted for publication. Absorption is the process by which a drug enters the bloodstream from the site of administration. Pharmacokinetics and biodistribution of rapamycin delivered.
As a service to our customers we are providing this early version of the manuscript. Furthermore, freshly emitted ceo2 nanoparticles can undergo an. The pharmacokinetics and in vivo biodistribution of optftc nps were investigated in male wistar rats via the oral administration. The pharmacokinetics, biodistribution, in vivo antitumor activity and safety of ptx. This signifies the advantage of ep nanoparticles in increasing the elimination half life of dox both after i.
To determine their biodistribution, the nanoparticles were administered to mice through their tail veins. Meansd n4 pharmacokinetics and biodistribution of pectin nanoparticles 101. Therefore, nonbiodegradable particles and degradation molecules with a molecular weight higher than the renal threshold, typically become sequestered in the mps organs. Templated polymer replica nanoparticles to facilitate. Read pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel, cancer nanotechnology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Opsonization, biodistribution, and pharmacokinetics of. Full text pharmacokinetic studies of nanoparticles as a. In this study, we investigated the pharmacokinetics, biodistribution, and tumor uptake of subnanometer sized polymeric nanoparticles particles were labeled with gamma emitter indium111. Factors influencing the pharmacokinetics of nanoparticles nps.
Rapid clearance of circulating nanoparticles during systemic delivery is a critical issue for these systems and has made it necessary to understand the factors affecting particle biodistribution and blood circulation halflife. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of. Because of uncertain toxicity, green synthesis methods are emerging, using plant extracts to improve biological and environmental compatibility. Drugparticle pharmacokinetics pk and biodistribution in lymphoid tissue macrophages proved equivalent, one with the other. In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats. Factors affecting the clearance and biodistribution of.
Here we explore the biodistribution of green aunps in mice and prepare a physiologicallybased. Pharmacokinetics and biodistribution of lonidaminepaclitaxel loaded, egfrtargeted nanoparticles in an orthotopic animal model of multidrug resistant breast cancer. The particles were subsequently found in some organs using an energydispersed xray spectrometer and inductively coupled plasmaatomic emission spectroscopy. Zeta potential, the net charge on a surface of a particle, is a major influential physical factor impacting pharmacokinetics and biodistribution of nanoparticles and is known to affect the. A high pdi indicates a broad distribution of nanoparticle diameters, which results in their multistage clearance since larger nanoparticles. A phase 0 study of the pharmacokinetics, biodistribution. This study evaluated the pharmacokinetics, biodistribution, dosimetry, and tumor. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of this molecule to specific targets in vivo. Through proper design and formulation of the chemical and physical properties of the nanoparticle, including surface chemistry and hydrodynamic radius, the pharmacokinetics and biodistribution can. On the other hand, small nanoparticles are more rapidly eliminated by the kidneys, as is the opposite with the larger rna nanoparticles. Pharmacokinetics, biodistribution, and antiangiogenesis. Pharmacokinetics and biodistribution of surface modification. In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron.
Since the initial opsonization of particles is so critical to the process of phagocytic recognition and clearance from the bloodstream, most research in the area of stealth. Coated bvpplanps were prepared by the spontaneous emulsification solvent diffusion method and characterized. Pharmacokinetics abstract understanding the pharmacokinetics, blood compatibility, biodistribution and clearance properties of nanoparticles is of great importance to their translation to clinical application. Sugars with their threedimensional structures are important for many biological functions. We report preparation of negatively charged pectin nanoparticles encapsulating paclitaxel, a broadspectrum anticancer drug for possible therapeutic applications. These values indicate a rapid and extensive distribution beyond the central. Small rna nanoparticles, from one side, are less prone than the larger particles to be captured by macrophages of the reticuloendothelial system. Transmission electron microscopy studies on optftc nps demonstrated uniform shape and size of particles. Surface modification is frequently used to tailor the interactions of nanoparticles with biological systems. Background inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis and therapy. Factors affecting the pharmacokinetics, biodistribution and. Here we explore the biodistribution of green aunps in mice and prepare a physiologically. Pdf formulation, pharmacokinetics and biodistribution of. May 22, 2019 liposomes are drug nano carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention epr.
Discher, synthetic cells selfassembling polymer membranes and bioadhesive colloids, annu. The drug molecules in nanomedicine are the same as those in the conventional dosage forms, but due to alteration of physicochemical properties and other attributes, the pharmacokinetics and efficacy potential of the drugs are significantly transformed. Therefore, it is very important to monitor the pharmacokinetics pk and biodistribution of nanoparticles to understand and predict their. Pectin, a naturally occurring biopolymer has been found to have increasing applications in the pharmaceutical and biotechnology industry. Pharmacokinetics and biodistribution of negatively charged.
Liposomes are drug nano carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention epr. The pharmacokinetics and biodistribution studies on balbc mice indicated that the nanoparticles had prolonged plasma retention of the drug with major accumulation in liver tissue after an i. Pharmacokinetics and biodistribution of nearinfrared. Image guided biodistribution and pharmacokinetic studies. Pharmacokinetics and biodistribution of paclitaxelgelatin. Factors controlling the pharmacokinetics, biodistribution and. This understanding is important for a range of nanomedicine applications, especially those based on lbl technology. In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles. Pharmacokinetics and biodistribution of rapamycin delivered as inhalable particles to mice. Pdf pharmacokinetics and biodistribution of rgdtargeted. In several preclinical studies with various tumorbearing mice models, 188reliposome that has been developed by the institute of nuclear energy research iner demonstrates favorable in vivo tumor targeting, biodistribution, pharmacokinetics. Modulating pharmacokinetics, tumor uptake and biodistribution.
In many cases, the chemical nature of the treatments employed to modify the biological interface for example attachment of hydrophilic polymers or targeting groups is the focus of attention. Lipidbased nanocarriers such as self nano emulsifying lipidic nanomicellar systems snels were also used to deliver dtx. Biodistribution and pharmacokinetics study perepelyuk et al. The pharmacokinetics, biodistribution, in vivo antitumor activity and safety of ptx microemulsion. Finally, future directions for improving the pk of nanoparticles and. Cerium oxide ceo2 nanoparticles used as a diesel fuel additive can be emitted into the ambient air leading to human inhalation. Tuning pharmacokinetics and biodistribution of a targeted. Pharmacokinetics and biodistribution of nanoparticles molecular. The np core was composed of inulin multimethacrylate with a targeting peptide, cyclic rgd, covalently attached. We report the biodistribution and pharmacokinetics pk of a cyclic rgddoxorubicin nanoparticle np formulation in tumorbearing mice. Pharmacokinetic, pharmacodynamic and biodistribution following oral 1. Biodistribution, pharmacokinetics, and toxicity of. The pharmacokinetics pk and tissue distribution of the nanoparticles largely define their therapeutic effect and toxicity.
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